Necab2 N-terminal EF-hand calcium binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Necab2provided by RGD
Official Full Name: N-terminal EF-hand calcium binding protein 2provided by RGD
Primary source: RGD:621844
See related: EnsemblRapid:ENSRNOG00000015084 AllianceGenome:RGD:621844
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Efcbp2
Summary: Predicted to enable A2A adenosine receptor binding activity; identical protein binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be involved in positive regulation of protein localization to membrane; regulation of amyloid precursor protein biosynthetic process; and regulation of signal transduction. Is active in postsynapse and presynapse. Orthologous to human NECAB2 (N-terminal EF-hand calcium binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 67.9) and Adrenal (RPKM 8.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (64409627..64436371)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (47501351..47527722)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (52086325..52112633)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPV1, Targeted by miR-338-3p, Induces Neuropathic Pain by Interacting with NECAB2.
Title: TRPV1, Targeted by miR-338-3p, Induces Neuropathic Pain by Interacting with NECAB2.
NECAB2 by its physical interaction with mGlu(5b) receptor modulates receptor function
Title: The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI236754 (e-PCR)
- UniSTS:250628

RH130737 (e-PCR)
- UniSTS:214021

BF402232 (e-PCR)
- UniSTS:245877

BF387455 (e-PCR)
- UniSTS:244363

AU047953 (e-PCR)
- UniSTS:110017

d3rat22 (e-PCR)
- UniSTS:121843

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables A2A adenosine receptor binding	IEA Inferred from Electronic Annotation more info
enables A2A adenosine receptor binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables type 5 metabotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables type 5 metabotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of G protein-coupled receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid precursor protein biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: N-terminal EF-hand calcium-binding protein 2

Names: EF hand calcium binding protein 2; neuronal calcium binding 2; neuronal calcium-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133415.2 → NP_596906.2 N-terminal EF-hand calcium-binding protein 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

F1LQY6, Q9ESB4

UniProtKB/TrEMBL

A0A5H1ZRU5

Related

ENSRNOP00000100370.1, ENSRNOT00000148837.1

Conserved Domains (2) summary

pfam03992
Location:254 → 324

ABM; Antibiotic biosynthesis monooxygenase

pfam13499
Location:30 → 89

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

64409627..64436371

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277747.1 → XP_063133817.1 N-terminal EF-hand calcium-binding protein 2 isoform X3
XM_063277745.1 → XP_063133815.1 N-terminal EF-hand calcium-binding protein 2 isoform X1
XM_063277746.1 → XP_063133816.1 N-terminal EF-hand calcium-binding protein 2 isoform X2