Nat8f1 N-acetyltransferase 8 (GCN5-related) family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nat8f1provided by RGD
Full Name: N-acetyltransferase 8 (GCN5-related) family member 1provided by RGD
Primary source: RGD:621606
See related: EnsemblRapid:ENSRNOG00000015799 AllianceGenome:RGD:621606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cml2
Summary: Predicted to enable N-acetyltransferase activity. Predicted to be located in membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 392.9) and Brain (RPKM 25.4) See more
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Genomic context

Location:: 4q34

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (119893672..119900357, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (118336208..118342923, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (117582779..117589464, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation.
Title: Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables N-acetyltransferase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in gastrulation with mouth forming second	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: probable N-acetyltransferase CML1

Names: camello-like 1; camello-like protein 1; camello-like protein 2; probable N-acetyltransferase CML1-like; putative N-acetyltransferase Camello 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021668.3 → NP_067700.2 probable N-acetyltransferase CML1

See identical proteins and their annotated locations for NP_067700.2

Status: VALIDATED

Source sequence(s)

BC078836, CF114103

UniProtKB/Swiss-Prot

Q9QXT4

UniProtKB/TrEMBL

A6IAT8, V9GZ80

Related

ENSRNOP00000099381.1, ENSRNOT00000124870.1

Conserved Domains (2) summary

cd04301
Location:118 → 185

NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate

COG0456
Location:111 → 209

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]