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    Cdc42ep5 CDC42 effector protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc42ep5provided by RGD
    Official Full Name
    CDC42 effector protein 5provided by RGD
    Primary source
    RGD:1308382
    See related
    AllianceGenome:RGD:1308382
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to act upstream of or within JNK cascade. Predicted to be located in membrane. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human CDC42EP5 (CDC42 effector protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 41.2), Kidney (RPKM 38.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc42ep5 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (79108036..79110550)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (70035921..70038990)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (73717207..73719600)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B3 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene ornithine decarboxylase 1, pseudogene 7 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene leukocyte receptor cluster member 8 Neighboring gene tweety family member 1 Neighboring gene leukocyte-associated immunoglobulin-like receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. Hirsch DS, et al. J Biol Chem, 2001 Jan 12. PMID 11035016
    2. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Joberty G, et al. Mol Cell Biol, 1999 Oct. PMID 10490598, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cdc42 effector protein 5
    Names
    CDC42 effector protein (Rho GTPase binding) 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108469.1 → NP_001101939.1  cdc42 effector protein 5

      See identical proteins and their annotated locations for NP_001101939.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474075
      UniProtKB/TrEMBL
      A6KNJ9
      Conserved Domains (2) summary
      pfam14957
      Location:70 → 113
      BORG_CEP; Cdc42 effector
      cl00113
      Location:23 → 50
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      79108036..79110550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008758945.4 → XP_008757167.1  cdc42 effector protein 5 isoform X2

      See identical proteins and their annotated locations for XP_008757167.1

      UniProtKB/TrEMBL
      A6KNJ9
      Conserved Domains (2) summary
      pfam14957
      Location:70 → 113
      BORG_CEP; Cdc42 effector
      cl00113
      Location:23 → 50
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. XM_008758944.4 → XP_008757166.1  cdc42 effector protein 5 isoform X2

      See identical proteins and their annotated locations for XP_008757166.1

      UniProtKB/TrEMBL
      A6KNJ9
      Conserved Domains (2) summary
      pfam14957
      Location:70 → 113
      BORG_CEP; Cdc42 effector
      cl00113
      Location:23 → 50
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    3. XM_006228217.4 → XP_006228279.1  cdc42 effector protein 5 isoform X1

      Conserved Domains (2) summary
      pfam14957
      Location:121 → 168
      BORG_CEP; Cdc42 effector
      cl00113
      Location:78 → 105
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein Strain
    Heading Accession and Version

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