Mbtps1 membrane-bound transcription factor peptidase, site 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mbtps1provided by RGD
Official Full Name: membrane-bound transcription factor peptidase, site 1provided by RGD
Primary source: RGD:70935
See related: EnsemblRapid:ENSRNOG00000015173 AllianceGenome:RGD:70935
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S1p; Ski-1
Summary: Enables serine-type endopeptidase activity. Predicted to be involved in several processes, including lysosome organization; membrane protein intracellular domain proteolysis; and mitotic G2 DNA damage checkpoint signaling. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in Golgi stack. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kondo-Fu type. Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 281.9), Thymus (RPKM 281.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (64470245..64521438, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (47561598..47612769, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (52146507..52206310, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis.
Title: Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis.
Molecular Mechanism of the ATF6alpha/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats.
Title: Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats.
S1P affects and sustains all key cellular processes responsible for wound repair and point to a unique potential for this molecule in the therapy of diabetic wounds, particularly as an angiogenic agent in treatment of diabetic wounds.
Title: Sphingosine 1-phosphate accelerates wound healing in diabetic mice.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:225106 (e-PCR)
- UniSTS:225106

RH129347 (e-PCR)
- UniSTS:212654

RH127834 (e-PCR)
- UniSTS:211144

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	IEA Inferred from Electronic Annotation more info
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane protein intracellular domain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in membrane protein intracellular domain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: membrane-bound transcription factor site-1 protease

Names: S1P endopeptidase; endopeptidase S1P; membrane-bound transcription factor protease, site 1; site-1 protease; subtilisin/kexin isozyme 1

NP_446021.2

EC 3.4.21.112

XP_008770873.1

EC 3.4.21.112

XP_038953977.1

EC 3.4.21.112

XP_038953979.1

EC 3.4.21.112

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053569.2 → NP_446021.2 membrane-bound transcription factor site-1 protease precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

G3V7Z2, Q9WTZ3

UniProtKB/TrEMBL

A0A8L2R475

Related

ENSRNOP00000020838.4, ENSRNOT00000020838.9

Conserved Domains (2) summary

cd07479
Location:203 → 455

Peptidases_S8_SKI-1_like; Peptidase S8 family domain in SKI-1-like proteins

pfam14258
Location:651 → 724

DUF4350; Domain of unknown function (DUF4350)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

64470245..64521438 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098049.2 → XP_038953977.1 membrane-bound transcription factor site-1 protease isoform X2

Conserved Domains (2) summary

cd07479
Location:1 → 251

Peptidases_S8_SKI-1_like; Peptidase S8 family domain in SKI-1-like proteins

pfam14258
Location:447 → 520

DUF4350; Domain of unknown function (DUF4350)
XM_039098051.2 → XP_038953979.1 membrane-bound transcription factor site-1 protease isoform X3

Conserved Domains (1) summary

pfam14258
Location:133 → 206

DUF4350; Domain of unknown function (DUF4350)
XM_008772651.4 → XP_008770873.1 membrane-bound transcription factor site-1 protease isoform X1

UniProtKB/TrEMBL

A0A8I5XW81

Conserved Domains (3) summary

cd07479
Location:203 → 455

Peptidases_S8_SKI-1_like; Peptidase S8 family domain in SKI-1-like proteins

pfam00082
Location:209 → 464

Peptidase_S8; Subtilase family

pfam14258
Location:651 → 724

DUF4350; Domain of unknown function (DUF4350)