Cul4b cullin 4B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cul4bprovided by RGD
Official Full Name: cullin 4Bprovided by RGD
Primary source: RGD:1564494
See related: EnsemblRapid:ENSRNOG00000002585 AllianceGenome:RGD:1564494
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564494
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to contribute to damaged DNA binding activity. Involved in neuron projection development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 139.8), Thymus (RPKM 133.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq35

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (122154332..122192299, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (117287481..117326688, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (124831391..124870329, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis.
Title: Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis.
MiR-674-5p Suppresses the Proliferation and Migration of Glioma Cells by Targeting Cul4b.
Title: MiR-674-5p Suppresses the Proliferation and Migration of Glioma Cells by Targeting Cul4b.
CUL4B expression is up-regulated in synovium and FLS from adjuvant-induced arthritis (AIA) rats. Increased CUL4B promotes the canonical Wnt signaling and promotes the pathogenesis of AIA rats. Decreased miR-101-3p contributes to disordered CUL4B.
Title: CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G16011 (e-PCR)
- UniSTS:65807

RH141795 (e-PCR)
- UniSTS:223787

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in UV-damage excision repair	ISO Inferred from Sequence Orthology more info
involved_in astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ribosome biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4A-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4B-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4B-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cullin-4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106951.1 → NP_001100421.1 cullin-4B

See identical proteins and their annotated locations for NP_001100421.1

Status: PROVISIONAL

Source sequence(s)

CH473991

UniProtKB/TrEMBL

A0A8I6B5A8, A6JMK5, D3ZK73

Related

ENSRNOP00000060639.1, ENSRNOT00000065023.4

Conserved Domains (3) summary

smart00182
Location:654 → 794

CULLIN; Cullin

smart00884
Location:900 → 965

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:276 → 871

Cullin; Cullin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

122154332..122192299 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257489.5 → XP_006257551.1 cullin-4B isoform X1

UniProtKB/TrEMBL

A0A8I6B5A8

Conserved Domains (3) summary

smart00182
Location:592 → 732

CULLIN; Cullin

smart00884
Location:838 → 903

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:214 → 809

Cullin; Cullin family
XM_039099624.2 → XP_038955552.1 cullin-4B isoform X2

UniProtKB/TrEMBL

A0A8I6B5A8

Conserved Domains (2) summary

smart00884
Location:711 → 776

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:86 → 683

Cullin; Cullin family