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    miro-1 Mitochondrial Rho GTPase 1 [ Caenorhabditis elegans ]

    Gene ID: 177238, updated on 9-Dec-2024

    Summary

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    Official Symbol
    miro-1
    Official Full Name
    Mitochondrial Rho GTPase 1
    Primary source
    WormBase:WBGene00019544
    Locus tag
    CELE_K08F11.5
    See related
    AllianceGenome:WB:WBGene00019544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Involved in mitochondrion organization. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Is expressed in body wall muscle cell; intestine; neurons; and pharynx. Orthologous to human RHOT1 (ras homolog family member T1) and RHOT2 (ras homolog family member T2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See miro-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (4712825..4715807, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene COP9/Signalosome and eIF3 complex-shared subunit 1 Neighboring gene Tyrosine--tRNA ligase Neighboring gene Lipoprotein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span. Shen Y, et al. PLoS One, 2016. PMID 27064409, Free PMC Article
    2. Polarized localization of kinesin-1 and RIC-7 drives axonal mitochondria anterograde transport. Wu Y, et al. J Cell Biol, 2024 May 6. PMID 38470363, Free PMC Article
    3. MIRO-1 interacts with VDAC-1 to regulate mitochondrial membrane potential in Caenorhabditis elegans. Ren X, et al. EMBO Rep, 2023 Aug 3. PMID 37306041, Free PMC Article
    4. Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling. Fu H, et al. Nat Commun, 2020 Feb 26. PMID 32103012, Free PMC Article
    5. Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Mao K, et al. Cell Metab, 2019 May 7. PMID 30799287, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIRO-1 interacts with VDAC-1 to regulate mitochondrial membrane potential in Caenorhabditis elegans.
      Title: MIRO-1 interacts with VDAC-1 to regulate mitochondrial membrane potential in Caenorhabditis elegans.
    2. Wounding triggered mitochondrial fragmentation is independent of the GTPase DRP-1 but acts via the mitochondrial Rho GTPase MIRO-1 and cytosolic Ca(2+). The fragmented mitochondria and accelerated wound closure of fzo-1 mutants are dependent on MIRO-1 function.
      Title: Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling.
    3. miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span.
      Title: C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial outer membrane permeabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in organelle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial Rho GTPase 1
    NP_500620.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4712825..4715807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068219.4 → NP_500620.1  Mitochondrial Rho GTPase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94263
      Conserved Domains (6) summary
      cd01892
      Location:423 → 592
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:9 → 173
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      COG1100
      Location:425 → 608
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam00071
      Location:11 → 171
      Ras; Ras family
      pfam08355
      Location:352 → 417
      EF_assoc_1; EF hand associated
      pfam08356
      Location:225 → 306
      EF_assoc_2; EF hand associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94263.1

    Gene LinkOut

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