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    Y48G10A.3 Protein NDRG3 [ Caenorhabditis elegans ]

    Gene ID: 173217, updated on 9-Dec-2024

    Summary

    Official Symbol
    Y48G10A.3
    Official Full Name
    Protein NDRG3
    Primary source
    WormBase:WBGene00013020
    Locus tag
    CELE_Y48G10A.3
    See related
    AllianceGenome:WB:WBGene00013020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in signal transduction. Located in striated muscle dense body. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to several human genes including NDRG1 (N-myc downstream regulated 1); NDRG2 (NDRG family member 2); and NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Y48G10A.3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (13470592..13474185, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene INTegrator complex Subunit homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase UBR7;RING-type E3 ubiquitin transferase Neighboring gene S-formylglutathione hydrolase

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    located_in striated muscle dense body PubMed 

    General protein information

    Preferred Names
    Protein NDRG3
    NP_493369.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13470592..13474185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060968.7NP_493369.1  Protein NDRG3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U283
      Conserved Domains (2) summary
      COG0596
      Location:38310
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:26314
      Ndr; Ndr family
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