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    apy-1 Apyrase apy-1 [ Caenorhabditis elegans ]

    Gene ID: 181019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    apy-1
    Official Full Name
    Apyrase apy-1
    Primary source
    WormBase:WBGene00017244
    Locus tag
    CELE_F08C6.6
    See related
    AllianceGenome:WB:WBGene00017244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GDP phosphatase activity and UDP phosphatase activity. Involved in several processes, including determination of adult lifespan; endoplasmic reticulum unfolded protein response; and ribonucleoside diphosphate catabolic process. Located in membrane. Is expressed in hypodermis and pharynx. Human ortholog(s) of this gene implicated in Desbuquois dysplasia and multiple epiphyseal dysplasia 7. Orthologous to human CANT1 (calcium activated nucleotidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See apy-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (7568141..7569722, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Band 7 domain-containing protein;Stomatin-1 Neighboring gene Vacuolar protein sorting-associated protein 52 homolog Neighboring gene Zinc finger protein unc-98 Neighboring gene Putative choline-phosphate cytidylyltransferase;choline-phosphate cytidylyltransferase Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses. Uccelletti D, et al. Mol Biol Cell, 2008 Apr. PMID 18216284, Free PMC Article
    2. An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Budovskaya YV, et al. Cell, 2008 Jul 25. PMID 18662544, Free PMC Article
    3. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Sawyer JM, et al. Genetics, 2011 Jul. PMID 21527776, Free PMC Article
    4. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    5. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables GDP phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables UDP phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATF6-mediated unfolded protein response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in GDP catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in GDP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in IRE1-mediated unfolded protein response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in UDP catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in UDP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Apyrase apy-1
    NP_509283.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7568141..7569722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076882.11 → NP_509283.1  Apyrase apy-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509283.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19202
      Conserved Domains (1) summary
      pfam06079
      Location:65 → 354
      Apyrase; Apyrase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19202.2

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