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    kqt-2 Ion transport domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181078, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kqt-2
    Official Full Name
    Ion transport domain-containing protein
    Primary source
    WormBase:WBGene00002234
    Locus tag
    CELE_M60.5
    See related
    AllianceGenome:WB:WBGene00002234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable outward rectifier potassium channel activity. Involved in defecation. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in amphid neurons; intestine; sensory neurons; tail; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kqt-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (8243131..8246369, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Endoribonuclease Neighboring gene Tetraspanin family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation. Wei AD, et al. J Biol Chem, 2005 Jun 3. PMID 15797864
    2. Cold acclimation via the KQT-2 potassium channel is modulated by oxygen in Caenorhabditis elegans. Okahata M, et al. Sci Adv, 2019 Feb. PMID 30775442, Free PMC Article
    3. Efficient isolation of targeted Caenorhabditis elegans deletion strains using highly thermostable restriction endonucleases and PCR. Wei A, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384612, Free PMC Article
    4. Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program. Nehrke K, et al. Am J Physiol Cell Physiol, 2008 Jan. PMID 17942636
    5. Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease. Jia F, et al. Cell Rep, 2020 Feb 11. PMID 32049015, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ion transport domain-containing protein
    NP_509392.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8243131..8246369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076991.7 → NP_509392.3  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509392.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYM8
      Conserved Domains (1) summary
      pfam00520
      Location:96 → 318
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version

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