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    acox-3 Acyl-coenzyme A oxidase acox-3 [ Caenorhabditis elegans ]

    Gene ID: 177386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acox-3
    Official Full Name
    Acyl-coenzyme A oxidase acox-3
    Primary source
    WormBase:WBGene00019060
    Locus tag
    CELE_F58F9.7
    See related
    AllianceGenome:WB:WBGene00019060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Involved in ascaroside biosynthetic process. Located in peroxisome. Is expressed in intestinal cell. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acox-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (6245358..6248492, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans. Zhang X, et al. Proc Natl Acad Sci U S A, 2016 Sep 6. PMID 27551084, Free PMC Article
    2. Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths. Zhang X, et al. ACS Chem Biol, 2018 Apr 20. PMID 29537254
    3. Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans. Wang Y, et al. J Biol Chem, 2022 Aug. PMID 35752365, Free PMC Article
    4. Endocrine pheromones couple fat rationing to dauer diapause through HNF4α nuclear receptors. Gao C, et al. Sci China Life Sci, 2021 Dec. PMID 34755252
    5. Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans. Zhou Y, et al. Elife, 2018 Jun 4. PMID 29863473, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    NOT enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pristanoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascaroside biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-coenzyme A oxidase acox-3
    NP_500943.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6245358..6248492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068542.8 → NP_500943.1  Acyl-coenzyme A oxidase acox-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500943.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20992
      Conserved Domains (1) summary
      cd01150
      Location:4 → 642
      AXO; Peroxisomal acyl-CoA oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20992.1

    Gene LinkOut

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