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    mca-1 Plasma membrane calcium-transporting ATPase mca-1 [ Caenorhabditis elegans ]

    Gene ID: 177795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mca-1
    Official Full Name
    Plasma membrane calcium-transporting ATPase mca-1
    Primary source
    WormBase:WBGene00003151
    Locus tag
    CELE_W09C2.3
    See related
    AllianceGenome:WB:WBGene00003151
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables P-type calcium transporter activity and calmodulin binding activity. Involved in calcium ion transport and intracellular calcium ion homeostasis. Located in membrane. Is expressed in excretory canal. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mca-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (9625909..9634948, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DEgenerin Like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and functional expression of the plasma membrane calcium ATPase gene family from Caenorhabditis elegans. Kraev A, et al. J Biol Chem, 1999 Feb 12. PMID 9933625
    2. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Plasma membrane calcium-transporting ATPase mca-1
    NP_001023426.1
    • Partially confirmed by transcript evidence
    NP_001023427.1
    • Confirmed by transcript evidence
    NP_001255409.1
    • Confirmed by transcript evidence
    NP_501709.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9625909..9634948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028256.7 → NP_001023427.1  Plasma membrane calcium-transporting ATPase mca-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC04
      Conserved Domains (5) summary
      TIGR01517
      Location:43 → 1084
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:222 → 465
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:902 → 1080
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:63 → 130
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:529 → 621
      Cation_ATPase; Cation transport ATPase (P-type)

    2. NM_001028255.5 → NP_001023426.1  Plasma membrane calcium-transporting ATPase mca-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC39
      Conserved Domains (5) summary
      TIGR01517
      Location:5 → 1063
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:201 → 444
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:881 → 1059
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:42 → 109
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:508 → 600
      Cation_ATPase; Cation transport ATPase (P-type)

    3. NM_069308.6 → NP_501709.2  Plasma membrane calcium-transporting ATPase mca-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501709.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F5GU98, G5EC04, G5EC39, G5EFR6
      Conserved Domains (5) summary
      TIGR01517
      Location:46 → 1087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:225 → 468
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:905 → 1083
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:66 → 133
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:532 → 624
      Cation_ATPase; Cation transport ATPase (P-type)

    4. NM_001268480.3 → NP_001255409.1  Plasma membrane calcium-transporting ATPase mca-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GU98
      Conserved Domains (4) summary
      TIGR01494
      Location:40 → 760
      ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC
      pfam00122
      Location:58 → 301
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:738 → 916
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam13246
      Location:365 → 457
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version

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