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    stau-1 DRBM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stau-1
    Official Full Name
    DRBM domain-containing protein
    Primary source
    WormBase:WBGene00018857
    Locus tag
    CELE_F55A4.5
    See related
    AllianceGenome:WB:WBGene00018857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables double-stranded RNA binding activity. Involved in germ cell development and negative regulation of post-transcriptional gene silencing by regulatory ncRNA. Predicted to be located in dendrite cytoplasm. Predicted to be active in several cellular components, including cytoplasmic stress granule; neuron projection; and neuronal cell body. Is expressed in body wall musculature; enteric muscle; nervous system; and pharynx. Orthologous to several human genes including STAU1 (staufen double-stranded RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See stau-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (1027668..1035286, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Stress-associated endoplasmic reticulum protein Neighboring gene pseudo Neighboring gene Vesicle-trafficking protein SEC22b Neighboring gene Ovule protein Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Staufen Negatively Modulates MicroRNA Activity in Caenorhabditis elegans. Ren Z, et al. G3 (Bethesda), 2016 May 3. PMID 26921297, Free PMC Article
    2. Aversive olfactory learning and associative long-term memory in Caenorhabditis elegans. Amano H, et al. Learn Mem, 2011 Oct. PMID 21960709, Free PMC Article
    3. Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene. Cuppen E, et al. Genome Res, 2007 May. PMID 17416746, Free PMC Article
    4. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
    5. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans
      Title: RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport of messenger ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular mRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of post-transcriptional gene silencing by regulatory ncRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DRBM domain-containing protein
    NP_508196.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1027668..1035286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075795.5 → NP_508196.1  DRBM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94239
      Conserved Domains (2) summary
      smart00358
      Location:79 → 142
      DSRM; Double-stranded RNA binding motif
      pfam16482
      Location:637 → 700
      Staufen_C; Staufen C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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