vps-35 Vacuolar protein sorting-associated protein 35 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: vps-35
Official Full Name: Vacuolar protein sorting-associated protein 35
Primary source: WormBase:WBGene00006933
Locus tag: CELE_F59G1.3
See related: AllianceGenome:WB:WBGene00006933
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in positive regulation of protein localization to cell periphery; protein localization to postsynaptic membrane; and regulation of presynapse assembly. Located in cytosol; dendrite; and neuronal cell body. Is expressed in several structures, including body wall musculature; ciliated neurons; coelomocyte; intestine; and pharynx. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The retromer protein vps-35 is required in Wnt-expressing cells.
Title: Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to cell periphery	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IMP Inferred from Mutant Phenotype more info	PubMed
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info
part_of retromer, cargo-selective complex	IEA Inferred from Electronic Annotation more info

NP_495180.2

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain