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    psf-3 DNA replication complex GINS protein PSF3 [ Caenorhabditis elegans ]

    Gene ID: 171645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psf-3
    Official Full Name
    DNA replication complex GINS protein PSF3
    Primary source
    WormBase:WBGene00022043
    Locus tag
    CELE_Y65B4BR.8
    See related
    AllianceGenome:WB:WBGene00022043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitotic DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of GINS complex. Orthologous to human GINS3 (GINS complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See psf-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (534455..535344)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene ncRNA Neighboring gene Nascent polypeptide-associated complex subunit alpha Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans. Ossareh-Nazari B, et al. G3 (Bethesda), 2016 Oct 13. PMID 27543292, Free PMC Article
    2. PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo. Benkemoun L, et al. J Cell Biol, 2014 May 26. PMID 24841566, Free PMC Article
    3. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Franz A, et al. Mol Cell, 2011 Oct 7. PMID 21981920, Free PMC Article
    4. DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Xia Y, et al. Science, 2023 Sep 22. PMID 37590372, Free PMC Article
    5. CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville R, et al. Nat Cell Biol, 2017 May. PMID 28368371, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication complex GINS protein PSF3
    NP_490748.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      534455..535344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058347.7 → NP_490748.1  DNA replication complex GINS protein PSF3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL54
      Conserved Domains (1) summary
      cd11713
      Location:72 → 179
      GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
    Nucleotide Protein
    Heading Accession and Version

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