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    F41H10.4 GRIP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F41H10.4
    Official Full Name
    GRIP domain-containing protein
    Primary source
    WormBase:WBGene00018317
    Locus tag
    CELE_F41H10.4
    See related
    AllianceGenome:WB:WBGene00018317
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in neurotransmitter receptor transport, endosome to postsynaptic membrane; regulation of intracellular transport; and regulation of modification of synaptic structure. Predicted to be active in glutamatergic synapse and postsynaptic recycling endosome. Predicted to be extrinsic component of postsynaptic early endosome membrane. Orthologous to human GRIPAP1 (GRIP1 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F41H10.4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (5364559..5366751)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Histone deacetylase 6;UBP-type domain-containing protein Neighboring gene TLC domain-containing protein Neighboring gene ncRNA Neighboring gene Vacuolar fusion protein MON1 homolog Neighboring gene PHD-type domain-containing protein;RNA-directed RNA polymerase Neighboring gene Long chain fatty acid elongase 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043
    2. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of modification of synaptic structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of recycling endosome localization within postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extrinsic component of postsynaptic early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GRIP domain-containing protein
    NP_500790.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5364559..5366751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068389.6 → NP_500790.1  GRIP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20298
      Conserved Domains (1) summary
      COG1196
      Location:62 → 404
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version

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