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    flr-4 Serine/threonine-protein kinase flr-4 [ Caenorhabditis elegans ]

    Gene ID: 181604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flr-4
    Official Full Name
    Serine/threonine-protein kinase flr-4
    Primary source
    WormBase:WBGene00001468
    Locus tag
    CELE_F09B12.6
    See related
    AllianceGenome:WB:WBGene00001468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in defecation. Located in plasma membrane. Is expressed in intestine; isthmus; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See flr-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (15089397..15093585)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene UBX domain-containing protein Neighboring gene ncRNA Neighboring gene Low-density lipoprotein receptor-related protein 2 Neighboring gene Movement protein Neighboring gene Putative phospholipase B-like 2 Neighboring gene Palmitoyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegansflr-3(ut9) mutation is a loss-of-function insertion within the drl-1 locus. Honey KL, et al. MicroPubl Biol, 2023. PMID 38116473, Free PMC Article
    2. Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene-diet interaction that ensures optimal life span. Nair T, et al. Aging Cell, 2022 Jan. PMID 35032420, Free PMC Article
    3. A novel gene-diet pair modulates C. elegans aging. Verma S, et al. PLoS Genet, 2018 Aug. PMID 30125273, Free PMC Article
    4. Ultradian rhythm in the intestine of Caenorhabditis elegans is controlled by the C-terminal region of the FLR-1 ion channel and the hydrophobic domain of the FLR-4 protein kinase. Kobayashi Y, et al. Genes Cells, 2011 May. PMID 21518154
    5. FLR-4, a novel serine/threonine protein kinase, regulates defecation rhythm in Caenorhabditis elegans. Take-uchi M, et al. Mol Biol Cell, 2005 Mar. PMID 15647385, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans.
      Title: Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans.
    2. We identify a novel gene-diet pair and show that the adaptive capacity to different food-type is modulated by the protein kinase FLR-4. This protein prevents differential activation of the p38 MAPK pathway dependent on the food-type and consequently, the expression of cytoprotective genes by transcription factor NHR-8.
      Title: A novel gene-diet pair modulates C. elegans aging.
    3. Data show that FLR-1 and FLR-4 are often colocalized in the plasma membrane.
      Title: Ultradian rhythm in the intestine of Caenorhabditis elegans is controlled by the C-terminal region of the FLR-1 ion channel and the hydrophobic domain of the FLR-4 protein kinase.
    4. flr4 acts in the intestine to increase the length of defecation cycle periods
      Title: FLR-4, a novel serine/threonine protein kinase, regulates defecation rhythm in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase flr-4
    NP_510508.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15089397..15093585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078107.6 → NP_510508.1  Serine/threonine-protein kinase flr-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510508.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NLA1
      Conserved Domains (2) summary
      smart00220
      Location:40 → 323
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:40 → 323
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NLA1.1

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