nxt-1 NTF2-related export protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nxt-1
Official Full Name: NTF2-related export protein
Primary source: WormBase:WBGene00003836
Locus tag: CELE_Y71F9AM.5
See related: AllianceGenome:WB:WBGene00003836
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nuclear pore central transport channel. Orthologous to human NXT1 (nuclear transport factor 2 like export factor 1) and NXT2 (nuclear transport factor 2 like export factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nxt-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (2929777..2931361)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.
Title: The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y71F9A_279.b (e-PCR)
- UniSTS:324479

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NTF2-related export protein

NP_001122551.1

Confirmed by transcript evidence

NP_491077.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2929777..2931361

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129079.3 → NP_001122551.1 NTF2-related export protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122551.1

Status: REVIEWED

UniProtKB/TrEMBL

G8JYG1

Conserved Domains (1) summary

cd00780
Location:16 → 131

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_058676.6 → NP_491077.1 NTF2-related export protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491077.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U757

Conserved Domains (1) summary

cd00780
Location:16 → 137

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...