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    vab-2 Ephrin RBD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177140, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vab-2
    Official Full Name
    Ephrin RBD domain-containing protein
    Primary source
    WormBase:WBGene00006869
    Locus tag
    CELE_Y37E11AR.6
    See related
    AllianceGenome:WB:WBGene00006869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway and epidermis morphogenesis. Located in axon and external side of plasma membrane. Is expressed in several structures, including anterior ganglion; neuroblasts; neurons; somatic nervous system; and ventral ganglion (post). Human ortholog(s) of this gene implicated in craniofrontonasal syndrome and dysostosis. Orthologous to human EFNB1 (ephrin B1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vab-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (3761195..3766826, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ig-like domain-containing protein Neighboring gene Bestrophin homolog Neighboring gene Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Osmotic avoidance abnormal protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental Wiring of Specific Neurons Is Regulated by RET-1/Nogo-A in Caenorhabditis elegans. Torpe N, et al. Genetics, 2017 Jan. PMID 27821431, Free PMC Article
    2. Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching. Wu Z, et al. Proc Natl Acad Sci U S A, 2007 Sep 18. PMID 17848506, Free PMC Article
    3. Mechanisms of ephrin receptor protein kinase-independent signaling in amphid axon guidance in Caenorhabditis elegans. Grossman EN, et al. Genetics, 2013 Nov. PMID 23979582, Free PMC Article
    4. The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans. Chin-Sang ID, et al. Cell, 1999 Dec 23. PMID 10619431
    5. Muscle cell migrations of C. elegans are mediated by the alpha-integrin INA-1, Eph receptor VAB-1, and a novel peptidase homologue MNP-1. Tucker M, et al. Dev Biol, 2008 Jun 15. PMID 18452914, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ephrin receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ephrin RBD domain-containing protein
    NP_001294296.1
    • Confirmed by transcript evidence
    NP_500412.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3761195..3766826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068011.4 → NP_500412.1  Ephrin RBD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEE7
      Conserved Domains (1) summary
      cd02675
      Location:25 → 153
      Ephrin_ectodomain; Ectodomain of Ephrins

    2. NM_001307367.3 → NP_001294296.1  Ephrin RBD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PQX3
      Conserved Domains (1) summary
      cl19115
      Location:1 → 48
      Cupredoxin; Cupredoxin superfamily
    Nucleotide Protein
    Heading Accession and Version

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