hsp-110 Heat shock protein 110 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hsp-110
Official Full Name: Heat shock protein 110
Primary source: WormBase:WBGene00016250
Locus tag: CELE_C30C11.4
See related: AllianceGenome:WB:WBGene00016250
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable adenyl-nucleotide exchange factor activity. Involved in determination of adult lifespan; protein folding; and response to topologically incorrect protein. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to several human genes including HSPA4 (heat shock protein family A (Hsp70) member 4) and HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hsp-110 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (8443910..8446909, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The HSP110/HSP70 disaggregation system generates spreading-competent toxic alpha-synuclein species.
Title: The HSP110/HSP70 disaggregation system generates spreading-competent toxic α-synuclein species.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C30C11.4 (e-PCR)
- UniSTS:309187

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stress	IEA Inferred from Electronic Annotation more info
involved_in response to topologically incorrect protein	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Heat shock protein 110

NP_498868.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8443910..8446909 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066467.7 → NP_498868.1 Heat shock protein 110 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498868.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q05036

Conserved Domains (2) summary

cd10228
Location:2 → 387

HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins

pfam00012
Location:3 → 650

HSP70; Hsp70 protein