sec-11 Signal peptidase complex catalytic subunit SEC11 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sec-11
Official Full Name: Signal peptidase complex catalytic subunit SEC11
Primary source: WormBase:WBGene00021844
Locus tag: CELE_Y54E10BR.5
See related: AllianceGenome:WB:WBGene00021844
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peptidase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Orthologous to several human genes including SEC11C (SEC11 homolog C, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sec-11 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (3028325..3031092, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y54E10B_159.d (e-PCR)
- UniSTS:324420

Y54E10B_159.c (e-PCR)
- UniSTS:323744

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of membrane protein complex	IEA Inferred from Electronic Annotation more info
part_of signal peptidase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Signal peptidase complex catalytic subunit SEC11

NP_491092.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3028325..3031092 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058691.7 → NP_491092.1 Signal peptidase complex catalytic subunit SEC11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491092.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9N3D0

Conserved Domains (1) summary

cl10465
Location:41 → 178

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...