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    eor-2 EOR-2 [ Caenorhabditis elegans ]

    Gene ID: 181557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eor-2
    Official Full Name
    EOR-2
    Primary source
    WormBase:WBGene00001325
    Locus tag
    CELE_C44H4.7
    See related
    AllianceGenome:WB:WBGene00001325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including Ras protein signal transduction; nematode male tail tip morphogenesis; and neuron migration. Located in nucleus. Is expressed in several structures, including P3.p hermaphrodite; hyp12; neurons; ventral nerve cord; and vulval cell. Orthologous to human CCDC82 (coiled-coil domain containing 82). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eor-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    17
    Sequence:
    Chromosome: X; NC_003284.9 (14603017..14608660)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EOR-1 and EOR-2 function in RMED/V neuron specification. Huang X, et al. MicroPubl Biol, 2019 Jul 31. PMID 32550430, Free PMC Article
    2. New mutants defective in RMED/V neuron specification are alleles of EOR-1 and EOR-2. Huang X, et al. MicroPubl Biol, 2019 Jul 31. PMID 32550435, Free PMC Article
    3. eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegans. Hoeppner DJ, et al. Dev Biol, 2004 Oct 1. PMID 15355793
    4. EOR-2 is an obligate binding partner of the BTB-zinc finger protein EOR-1 in Caenorhabditis elegans. Howell K, et al. Genetics, 2010 Apr. PMID 20065070, Free PMC Article
    5. Transcriptional control of non-apoptotic developmental cell death in C. elegans. Malin JA, et al. Cell Death Differ, 2016 Dec. PMID 27472063, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the interaction between EOR-1 and EOR-2
      Title: EOR-2 is an obligate binding partner of the BTB-zinc finger protein EOR-1 in Caenorhabditis elegans.
    2. eor-1 and eor-2 function together throughout the nervous system to promote terminal differentiation of neurons and function specifically in male hermaphrodite-specific neurons to promote apoptotic death.
      Title: eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    EOR-2
    NP_001024470.1
    • Confirmed by transcript evidence
    NP_001024471.1
    • Confirmed by transcript evidence
    NP_001300307.1
    • Confirmed by transcript evidence
    NP_001300308.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14603017..14608660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029300.6 → NP_001024471.1  EOR-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGD8
      Conserved Domains (2) summary
      PHA03309
      Location:221 → 403
      PHA03309; transcriptional regulator ICP4; Provisional
      PRK10856
      Location:134 → 254
      PRK10856; cytoskeletal protein RodZ; Provisional

    2. NM_001313378.4 → NP_001300307.1  EOR-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASL2
      Conserved Domains (2) summary
      PHA03309
      Location:223 → 405
      PHA03309; transcriptional regulator ICP4; Provisional
      PRK10856
      Location:134 → 256
      PRK10856; cytoskeletal protein RodZ; Provisional

    3. NM_001029299.7 → NP_001024470.1  EOR-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE70
      Conserved Domains (2) summary
      PRK07003
      Location:189 → 381
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      PRK10856
      Location:134 → 254
      PRK10856; cytoskeletal protein RodZ; Provisional

    4. NM_001313379.4 → NP_001300308.1  EOR-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AW79
      Conserved Domains (1) summary
      pfam13926
      Location:143 → 271
      DUF4211; Domain of unknown function (DUF4211)
    Nucleotide Protein
    Heading Accession and Version

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