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    wip-1 WH2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wip-1
    Official Full Name
    WH2 domain-containing protein
    Primary source
    WormBase:WBGene00020094
    Locus tag
    CELE_R144.4
    See related
    AllianceGenome:WB:WBGene00020094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cytoskeletal regulatory protein binding activity. Involved in embryonic body morphogenesis; regulation of cell migration; and regulation of protein stability. Is expressed in hypodermis. Orthologous to human WIPF1 (WAS/WASL interacting protein family member 1); WIPF2 (WAS/WASL interacting protein family member 2); and WIPF3 (WAS/WASL interacting protein family member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wip-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (5018639..5021120)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF5683 domain-containing protein Neighboring gene La-related protein 1 Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 11 Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans WASP-interacting protein homologue WIP-1 is involved in morphogenesis through maintenance of WSP-1 protein levels. Sawa M, et al. Biochem Biophys Res Commun, 2006 Feb 10. PMID 16378591
    2. WIP-1 and DBN-1 promote scission of endocytic vesicles by bridging actin and Dynamin-1 in the C. elegans intestine. Shi X, et al. J Cell Sci, 2019 Jun 17. PMID 31118234
    3. Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents. Goloudina AR, et al. Proc Natl Acad Sci U S A, 2012 Jan 10. PMID 22065775, Free PMC Article
    4. Collagen and actin network mediate antiviral immunity against Orsay virus in C. elegans intestinal cells. Zhou Y, et al. PLoS Pathog, 2024 Jan. PMID 38190406, Free PMC Article
    5. Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans. Kimata T, et al. Genetics, 2012 Jun. PMID 22446320, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cortactin-binding domain of WIP-1 serves as the binding interface for DBN-1 (also known in other organisms as Abp1), another actin-binding protein
      Title: WIP-1 and DBN-1 promote scission of endocytic vesicles by bridging actin and Dynamin-1 in the C. elegans intestine.
    2. Wip1 phosphatase promotes apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.
      Title: Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal regulatory protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WH2 domain-containing protein
    NP_741122.2
    • Confirmed by transcript evidence
    NP_741123.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5018639..5021120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171109.4 → NP_741122.2  WH2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741122.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WT46
      Conserved Domains (1) summary
      smart00246
      Location:28 → 45
      WH2; Wiskott Aldrich syndrome homology region 2

    2. NM_171863.4 → NP_741123.2  WH2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741123.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ22
      Conserved Domains (1) summary
      smart00246
      Location:28 → 45
      WH2; Wiskott Aldrich syndrome homology region 2
    Nucleotide Protein
    Heading Accession and Version

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