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    slc-25A46 Solute carrier family 25 member 46 [ Caenorhabditis elegans ]

    Gene ID: 173212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc-25A46
    Official Full Name
    Solute carrier family 25 member 46
    Primary source
    WormBase:WBGene00012740
    Locus tag
    CELE_Y40B1B.8
    See related
    AllianceGenome:WB:WBGene00012740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial fission. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1E. Orthologous to human SLC25A46 (solute carrier family 25 member 46). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See slc-25A46 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (13428913..13434611)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene Coiled-coil domain-containing protein 86 Neighboring gene ncRNA Neighboring gene Eukaryotic translation initiation factor 3 30 kDa subunit Neighboring gene ncRNA Neighboring gene Lysine-specific histone demethylase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial membrane fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Solute carrier family 25 member 46
    NP_493364.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13428913..13434611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060963.9 → NP_493364.1  Solute carrier family 25 member 46 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2J0
      Conserved Domains (2) summary
      pfam00153
      Location:291 → 385
      Mito_carr; Mitochondrial carrier protein
      cl00216
      Location:351 → 424
      L-asparaginase_like; Bacterial L-asparaginases and related enzymes
    Nucleotide Protein
    Heading Accession and Version

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