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    hcp-4 HoloCentric chromosome binding Protein [ Caenorhabditis elegans ]

    Gene ID: 171964, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hcp-4
    Official Full Name
    HoloCentric chromosome binding Protein
    Primary source
    WormBase:WBGene00001832
    Locus tag
    CELE_T03F1.9
    See related
    AllianceGenome:WB:WBGene00001832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including kinetochore assembly; negative regulation of mitotic centrosome separation; and nuclear chromosome segregation. Located in cytoplasm; kinetochore; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hcp-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (3862833..3865938, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene Dimethyladenosine transferase 1, mitochondrial Neighboring gene guanylate kinase Neighboring gene putative phosphoglycerate kinase Neighboring gene Ubiquinone biosynthesis protein coq-4, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recurrent but Short-Lived Duplications of Centromeric Proteins in Holocentric Caenorhabditis Species. Caro L, et al. Mol Biol Evol, 2022 Oct 7. PMID 36173809, Free PMC Article
    2. HCP-4, a CENP-C-like protein in Caenorhabditis elegans, is required for resolution of sister centromeres. Moore LL, et al. J Cell Biol, 2001 Jun 11. PMID 11402064, Free PMC Article
    3. Evidence for centromere drive in the holocentric chromosomes of Caenorhabditis. Zedek F, et al. PLoS One, 2012. PMID 22291967, Free PMC Article
    4. BUB-1 and CENP-C recruit PLK-1 to control chromosome alignment and segregation during meiosis I in C. elegans oocytes. Taylor SJP, et al. Elife, 2023 Apr 17. PMID 37067150, Free PMC Article
    5. HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans. Moore LL, et al. Mol Cell Biol, 2005 Apr. PMID 15767665, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the knockdown of nucleoporins NPP-10, NPP-13 and NPP-20 in Caenorhabditiselegans affects early steps in centromere formation and sister centromere resolution, and results in severe chromosomal defects in the early embryo.
      Title: Nucleoporins NPP-10, NPP-13 and NPP-20 are required for HCP-4 nuclear import to establish correct centromere assembly.
    2. Although CENP-C did not show any signs of positive selection, positive selection has been detected in the case of CENH3.
      Title: Evidence for centromere drive in the holocentric chromosomes of Caenorhabditis.
    3. we found that the loss of proteins involved in chromosome cohesion bypassed the requirement for HCP-4/CENP-C but not for AIR-2
      Title: HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of protein localization to chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HoloCentric chromosome binding Protein
    NP_491244.1
    • Product from WormBase gene class hcp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3862833..3865938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058843.9 → NP_491244.1  HoloCentric chromosome binding Protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491244.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDA3
    Nucleotide Protein
    Heading Accession and Version

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