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    pfd-5 putative prefoldin subunit 5 [ Caenorhabditis elegans ]

    Gene ID: 176013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pfd-5
    Official Full Name
    putative prefoldin subunit 5
    Primary source
    WormBase:WBGene00020112
    Locus tag
    CELE_R151.9
    See related
    AllianceGenome:WB:WBGene00020112
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in RNA polymerase I assembly; RNA polymerase II core complex assembly; and RNA polymerase III assembly. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Orthologous to human PFDN5 (prefoldin subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pfd-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (7198151..7198884, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene CDT1 domain-containing protein Neighboring gene Exosome complex component RRP45 Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase dpy-31 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans. Lundin VF, et al. Dev Biol, 2008 Jan 1. PMID 18062952
    2. Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans. Son HG, et al. Genes Dev, 2018 Dec 1. PMID 30478249, Free PMC Article
    3. The nascent polypeptide-associated complex is a key regulator of proteostasis. Kirstein-Miles J, et al. EMBO J, 2013 May 15. PMID 23604074, Free PMC Article
    4. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988
    5. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II core complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative prefoldin subunit 5
    NP_498582.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7198151..7198884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066181.6 → NP_498582.1  putative prefoldin subunit 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21993
      Conserved Domains (1) summary
      TIGR00293
      Location:15 → 141
      TIGR00293; prefoldin, archaeal alpha subunit/eukaryotic subunit 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21993.1

    Gene LinkOut

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