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    deps-1 P-granule-associated protein deps-1 [ Caenorhabditis elegans ]

    Gene ID: 171642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    deps-1
    Official Full Name
    P-granule-associated protein deps-1
    Primary source
    WormBase:WBGene00022034
    Locus tag
    CELE_Y65B4BL.2
    See related
    AllianceGenome:WB:WBGene00022034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in regulatory ncRNA-mediated gene silencing. Located in P granule. Is expressed in germ line and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See deps-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (506473..509056)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ABC-type antigen peptide transporter Neighboring gene Transmembrane protein Neighboring gene Dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene Long-chain-fatty-acid--CoA ligase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DEPS-1 promotes P-granule assembly and RNA interference in C. elegans germ cells. Spike CA, et al. Development, 2008 Mar. PMID 18234720, Free PMC Article
    2. GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance. Chen W, et al. Nat Commun, 2022 Sep 9. PMID 36085149, Free PMC Article
    3. Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants. Barucci G, et al. Nat Cell Biol, 2020 Feb. PMID 32015436, Free PMC Article
    4. 26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. Han T, et al. Proc Natl Acad Sci U S A, 2009 Nov 3. PMID 19846761, Free PMC Article
    5. Germ Granules Coordinate RNA-Based Epigenetic Inheritance Pathways. Dodson AE, et al. Dev Cell, 2019 Sep 23. PMID 31402284, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
      Title: DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    P-granule-associated protein deps-1
    NP_001293193.1
    • Confirmed by transcript evidence
    NP_490742.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      506473..509056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058341.6 → NP_490742.1  P-granule-associated protein deps-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490742.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N303, V6CLC9

    2. NM_001306264.3 → NP_001293193.1  P-granule-associated protein deps-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLC9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N303.1

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