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    ZK697.8 putative 5-hydroxyisourate hydrolase ZK697.8 [ Caenorhabditis elegans ]

    Gene ID: 191414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZK697.8
    Official Full Name
    putative 5-hydroxyisourate hydrolase ZK697.8
    Primary source
    WormBase:WBGene00022808
    Locus tag
    CELE_ZK697.8
    See related
    AllianceGenome:WB:WBGene00022808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydroxyisourate hydrolase activity. Predicted to be involved in purine nucleobase metabolic process. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome 1; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZK697.8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (1748432..1749153, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene NR LBD domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class Z

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyisourate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in purine nucleobase metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative 5-hydroxyisourate hydrolase ZK697.8
    NP_503496.2
    • Predicted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1748432..1749153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071095.2 → NP_503496.2  putative 5-hydroxyisourate hydrolase ZK697.8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503496.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44578
      Conserved Domains (1) summary
      cd05822
      Location:28 → 136
      TLP_HIUase; HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44578.2

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