adr-2 Double-stranded RNA-specific adenosine deaminase adr-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: adr-2
Official Full Name: Double-stranded RNA-specific adenosine deaminase adr-2
Primary source: WormBase:WBGene00000080
Locus tag: CELE_T20H4.4
See related: AllianceGenome:WB:WBGene00000080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables double-stranded RNA adenosine deaminase activity. Involved in adenosine to inosine editing; determination of adult lifespan; and positive regulation of chemotaxis. Located in cytoplasm and nucleus. Is expressed in germ line. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; amyotrophic lateral sclerosis; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to several human genes including ADARB1 (adenosine deaminase RNA specific B1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See adr-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (7231039..7232882, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADR-2 regulates fertility and oocyte fate in Caenorhabditis elegans.
Title: ADR-2 regulates fertility and oocyte fate in Caenorhabditis elegans.
Double-stranded RNA-specific adenosine deaminase adr-2 (ADR-2) has a reduced affinity for substrate RNAs compared to other ADARs.
Title: A protein-protein interaction underlies the molecular basis for substrate recognition by an adenosine-to-inosine RNA-editing enzyme.
Intersecting the neural editome with adr-2 associated gene expression changes, revealed an edited mRNA, clec-41, whose neural expression is dependent on deamination by ADR-2.
Title: The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis.
ADARs (ADR-1 and ADR-2), through both direct and indirect mechanisms, are important for maintaining wild-type levels of many small RNAs in C. elegans.
Title: Effects of ADARs on small RNA processing pathways in C. elegans.
results suggest that ADARs play a role in regulating whether a dsRNA enters the RNAi pathway
Title: Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T20H4.5 (e-PCR)
- UniSTS:318512

STS3-159 (e-PCR)
- UniSTS:242000

T20H4.4 (e-PCR)
- UniSTS:310919

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tRNA-specific adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine to inosine editing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Double-stranded RNA-specific adenosine deaminase adr-2

NP_498594.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7231039..7232882 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066193.5 → NP_498594.1 Double-stranded RNA-specific adenosine deaminase adr-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498594.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76295, Q22618

Conserved Domains (2) summary

smart00552
Location:132 → 493

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam00035
Location:37 → 102

dsrm; Double-stranded RNA binding motif