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    • Showing Current items.

    pfn-3 Profilin-3 [ Caenorhabditis elegans ]

    Gene ID: 180460, updated on 9-Dec-2024

    Summary

    Official Symbol
    pfn-3
    Official Full Name
    Profilin-3
    Primary source
    WormBase:WBGene00003991
    Locus tag
    CELE_K03E6.6
    See related
    AllianceGenome:WB:WBGene00003991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin monomer binding activity. Involved in muscle thin filament assembly. Located in striated muscle dense body. Is expressed in body wall musculature; intestine; and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See pfn-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (1079430..1080649, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Band 7 domain-containing protein;Protein unc-1 Neighboring gene B9 domain-containing protein 1 Neighboring gene LIM/homeobox protein lim-6 Neighboring gene Guanine nucleotide exchange factor rei-2 Neighboring gene tRNA-Arg Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in muscle thin filament assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sequestering of actin monomers IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Profilin-3
    NP_508205.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1079430..1080649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075804.7NP_508205.1  Profilin-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508205.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21193, Q5GHR0
      Conserved Domains (1) summary
      cd00148
      Location:2126
      PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...