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    atgp-2 Aamy domain-containing protein;Glycosyl hydrolase family 13 catalytic domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atgp-2
    Official Full Name
    Aamy domain-containing protein;Glycosyl hydrolase family 13 catalytic domain-containing protein
    Primary source
    WormBase:WBGene00000225
    Locus tag
    CELE_C38C6.2
    See related
    AllianceGenome:WB:WBGene00000225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atgp-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (14640098..14644083, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene Serpentine receptor class epsilon-13 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein Neighboring gene Protein-cysteine N-palmitoyltransferase HHAT Neighboring gene DUF148 domain-containing protein;Phage protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aromatic amino acid transporter AAT-9 of Caenorhabditis elegans localizes to neurons and muscle cells. Veljkovic E, et al. J Biol Chem, 2004 Nov 19. PMID 15364921
    2. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article
    3. Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters. Veljkovic E, et al. J Biol Chem, 2004 Feb 27. PMID 14668347
    4. Autophagy of germ-granule components, PGL-1 and PGL-3, contributes to DNA damage-induced germ cell apoptosis in C. elegans. Min H, et al. PLoS Genet, 2019 May. PMID 31125345, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of amino acid transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Aamy domain-containing protein;Glycosyl hydrolase family 13 catalytic domain-containing protein
    NP_001254435.1
    • Confirmed by transcript evidence
    NP_001254436.1
    • Confirmed by transcript evidence
    NP_001254437.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14640098..14644083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267506.4 → NP_001254435.1  Glycosyl hydrolase family 13 catalytic domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45298
      Conserved Domains (2) summary
      pfam16028
      Location:78 → 135
      SLC3A2_N; Solute carrier family 3 member 2 N-terminus
      cl38930
      Location:130 → 553
      AmyAc_family; Alpha amylase catalytic domain family

    2. NM_001267507.3 → NP_001254436.1  Glycosyl hydrolase family 13 catalytic domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G1K108
      Conserved Domains (2) summary
      pfam16028
      Location:34 → 91
      SLC3A2_N; Solute carrier family 3 member 2 N-terminus
      cl38930
      Location:86 → 509
      AmyAc_family; Alpha amylase catalytic domain family

    3. NM_001267508.3 → NP_001254437.1  Aamy domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G1K110
      Conserved Domains (1) summary
      cl38930
      Location:1 → 97
      AmyAc_family; Alpha amylase catalytic domain family
    Nucleotide Protein
    Heading Accession and Version

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