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    rnh-1.0 Ribonuclease H1;Ribonuclease H1 N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnh-1.0
    Official Full Name
    Ribonuclease H1;Ribonuclease H1 N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00004382
    Locus tag
    CELE_F59A6.6
    See related
    AllianceGenome:WB:WBGene00004382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2. Orthologous to human RNASEH1 (ribonuclease H1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rnh-1.0 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (4995327..4998035)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene SUI1 domain-containing protein Neighboring gene Mannosyltransferase Neighboring gene Charged multivesicular body protein 3 Neighboring gene Conserved secreted protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene TIL domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome. Arudchandran A, et al. Mol Biol Evol, 2002 Nov. PMID 12411600
    2. Stage-specific expression of Caenorhabditis elegans ribonuclease H1 enzymes with different substrate specificities and bivalent cation requirements. Kochiwa H, et al. FEBS J, 2006 Jan. PMID 16403028
    3. R-loop-induced irreparable DNA damage evades checkpoint detection in the C. elegans germline. Hicks T, et al. Nucleic Acids Res, 2022 Aug 12. PMID 35871299, Free PMC Article
    4. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA-DNA hybrid ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, removal of RNA primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ribonuclease H1;Ribonuclease H1 N-terminal domain-containing protein
    NP_001040786.1
    • Confirmed by transcript evidence
    NP_001379921.1
    • Confirmed by transcript evidence
    NP_871982.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4995327..4998035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393062.1 → NP_001379921.1  Ribonuclease H1 N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21024
      Conserved Domains (1) summary
      pfam01693
      Location:3 → 46
      Cauli_VI; Caulimovirus viroplasmin

    2. NM_182182.8 → NP_871982.1  Ribonuclease H1 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86MP4
      Conserved Domains (1) summary
      pfam01693
      Location:5 → 46
      Cauli_VI; Caulimovirus viroplasmin

    3. NM_001047321.2 → NP_001040786.1  Ribonuclease H1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86MG7
      Conserved Domains (3) summary
      COG3341
      Location:1 → 226
      Rnh1; RNase HI-related protein, contains viroplasmin and RNaseH domains [General function prediction only]
      cd09280
      Location:104 → 245
      RNase_HI_eukaryote_like; Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts
      pfam01693
      Location:8 → 49
      Cauli_VI; Caulimovirus viroplasmin
    Nucleotide Protein
    Heading Accession and Version

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