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    dpy-31 Zinc metalloproteinase dpy-31 [ Caenorhabditis elegans ]

    Gene ID: 176014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpy-31
    Official Full Name
    Zinc metalloproteinase dpy-31
    Primary source
    WormBase:WBGene00006592
    Locus tag
    CELE_R151.5
    See related
    AllianceGenome:WB:WBGene00006592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in extracellular region. Is expressed in several structures, including amphid sheath cell; excretory duct; hypodermis; socket cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dpy-31 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (7202661..7207664)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative prefoldin subunit 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein eL6 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31. France DJ, et al. Bioorg Med Chem Lett, 2015 Dec 15. PMID 26546217, Free PMC Article
    2. A highly conserved, inhibitable astacin metalloprotease from Teladorsagia circumcincta is required for cuticle formation and nematode development. Stepek G, et al. Int J Parasitol, 2015 Apr. PMID 25736599, Free PMC Article
    3. Collagen processing and cuticle formation is catalysed by the astacin metalloprotease DPY-31 in free-living and parasitic nematodes. Stepek G, et al. Int J Parasitol, 2010 Apr. PMID 19883650
    4. hch-1, a gene required for normal hatching and normal migration of a neuroblast in C. elegans, encodes a protein related to TOLLOID and BMP-1. Hishida R, et al. EMBO J, 1996 Aug 15. PMID 8861940, Free PMC Article
    5. Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target. Novelli J, et al. Genetics, 2004 Nov. PMID 15579684, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the roles of dpy-31, sqt-3, and dpy-17 in nematode collagen assembly
      Title: The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.
    2. Responsible for C-terminal proteolytic processing of collagen trimers, homolog of vertebrate BMP-1.
      Title: Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc metalloproteinase dpy-31
    NP_001022731.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7202661..7207664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027560.6 → NP_001022731.1  Zinc metalloproteinase dpy-31 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022731.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P98060, Q6AHR4
      Conserved Domains (4) summary
      smart00042
      Location:383 → 483
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00209
      Location:493 → 539
      TSP1; Thrombospondin type 1 repeats
      cd04280
      Location:139 → 324
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:134 → 327
      Astacin; Astacin (Peptidase family M12A)

    RNA

    1. NR_132452.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98060.2

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