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    aagr-4 Glycoside hydrolase family 31 N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180400, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aagr-4
    Official Full Name
    Glycoside hydrolase family 31 N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00018682
    Locus tag
    CELE_F52D1.1
    See related
    AllianceGenome:WB:WBGene00018682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alpha-glucosidase activity. Predicted to be involved in N-glycan processing. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to human GANAB (glucosidase II alpha subunit) and GANC (glucosidase alpha, neutral C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aagr-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (460651..466899)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Gag-pol polyprotein Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene Protein quiver Neighboring gene WD_REPEATS_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid alpha-glucosidase in Caenorhabditis elegans. Sikora J, et al. Mol Cell Biochem, 2010 Aug. PMID 20349118
    2. Gut commensal E. coli outer membrane proteins activate the host food digestive system through neural-immune communication. Geng S, et al. Cell Host Microbe, 2022 Oct 12. PMID 36057258
    3. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
    4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Glycoside hydrolase family 31 N-terminal domain-containing protein
    NP_508105.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      460651..466899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075704.7 → NP_508105.2  Glycoside hydrolase family 31 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508105.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17352
      Conserved Domains (4) summary
      cd06603
      Location:336 → 804
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:197 → 336
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam16338
      Location:61 → 146
      DUF4968; Domain of unknown function (DUF4968)
      pfam17137
      Location:779 → 852
      DUF5110; Domain of unknown function (DUF5110)
    Nucleotide Protein
    Heading Accession and Version

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