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    prx-5 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prx-5
    Official Full Name
    TPR_REGION domain-containing protein
    Primary source
    WormBase:WBGene00004194
    Locus tag
    CELE_C34C6.6
    See related
    AllianceGenome:WB:WBGene00004194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables peroxisome targeting sequence binding activity. Involved in nematode larval development and protein import into peroxisome matrix. Predicted to be active in cytosol and peroxisomal membrane. Is expressed in hypodermis; intestine; and neurons. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to several human genes including PEX5 (peroxisomal biogenesis factor 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prx-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (8704824..8706760)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Sphingosine kinase 1 Neighboring gene Homeobox protein ceh-7 Neighboring gene Uncharacterized protein Neighboring gene Serpentine receptor class gamma-15 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Predicting the function and subcellular location of Caenorhabditis elegans proteins similar to Saccharomyces cerevisiae beta-oxidation enzymes. Gurvitz A, et al. Yeast, 2000 Sep 30. PMID 11025529, Free PMC Article
    2. The tetratricopeptide repeat domains of human, tobacco, and nematode PEX5 proteins are functionally interchangeable with the analogous native domain for peroxisomal import of PTS1-terminated proteins in yeast. Gurvitz A, et al. Mol Genet Genomics, 2001 Apr. PMID 11361338
    3. HLH-30-dependent rewiring of metabolism during starvation in C. elegans. Dall KB, et al. Aging Cell, 2021 Apr. PMID 33724708, Free PMC Article
    4. Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans. Wang R, et al. PLoS One, 2013. PMID 24086720, Free PMC Article
    5. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxisome matrix targeting signal-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxisome targeting sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TPR_REGION domain-containing protein
    NP_001022019.1
    • Confirmed by transcript evidence
    NP_001022020.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8704824..8706760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026848.6 → NP_001022019.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18426
      Conserved Domains (3) summary
      COG0457
      Location:181 → 455
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG5010
      Location:355 → 462
      TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]
      sd00006
      Location:360 → 388
      TPR; TPR repeat [structural motif]

    2. NM_001026849.4 → NP_001022020.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022020.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JM90
      Conserved Domains (3) summary
      COG0457
      Location:179 → 453
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG5010
      Location:353 → 460
      TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]
      sd00006
      Location:358 → 386
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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