xbp-1 X-box-binding protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: xbp-1
Official Full Name: X-box-binding protein 1
Primary source: WormBase:WBGene00006959
Locus tag: CELE_R74.3
See related: AllianceGenome:WB:WBGene00006959
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including ERAD pathway; IRE1-mediated unfolded protein response; and determination of adult lifespan. Acts upstream of with a positive effect on negative regulation of multicellular organismal process. Predicted to be active in nucleus. Is expressed in several structures, including intestine. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See xbp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (4193809..4195358)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UPR[ER]-immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food.
Title: UPR(ER)-immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food.
Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPR(ER) Activation and Behavior in C. elegans.
Title: Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPR(ER) Activation and Behavior in C. elegans.
Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons.
Title: Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons.
A Functional Non-coding RNA Is Produced from xbp-1 mRNA.
Title: A Functional Non-coding RNA Is Produced from xbp-1 mRNA.
XBP-1 regulates lipid metabolism and contributes to its downstream effects on protein homeostasis and longevity.
Title: XBP-1 Remodels Lipid Metabolism to Extend Longevity.
Neuronal XBP-1s increases the expression of genes involved in lysosome function. Lysosomes in the intestine of animals expressing neuronal XBP-1s are more acidic, and lysosomal protease activity is higher.
Title: Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans.
vitamin-D3-induced lifespan extension requires the stress response pathway genes skn-1, ire-1, and xbp-1.
Title: Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.
In conclusion, we identified PEK-1 as a mediator of hormesis in the mev-1 mutant of C. elegans which is induced by simultaneous inhibition of XBP-1 and its splicing activator IRE-1 and mediated through activation of the proteasome.
Title: PEK-1 is crucial for hormesis induced by inhibition of the IRE-1/XBP-1 pathway in the Caenorhabditis elegans mev-1 mutant.
Our results indicated that abolishing sumoylation enhanced calreticulin expression in an XBP-1-dependent manner, and the resulting increase in calreticulin counteracted ER stress.
Title: Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans.
RTCB-1 (worm ortholog of human HSPC117) is required for the neuroprotective role, which, in turn, is mediated through XBP-1 in a model of neurodegenerative disease.
Title: RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R74.4 (e-PCR)
- UniSTS:310581

R74.3 (e-PCR)
- UniSTS:306527

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in IRE1-mediated unfolded protein response	IEP Inferred from Expression Pattern more info	PubMed
involved_in IRE1-mediated unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect negative regulation of multicellular organismal process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to topologically incorrect protein	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: X-box-binding protein 1

NP_001076646.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4193809..4195358

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001083177.4 → NP_001076646.1 X-box-binding protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076646.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EE07, Q8WRF0

Conserved Domains (1) summary

cd14691
Location:61 → 118

bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain