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    ZK287.4 BPTI/Kunitz inhibitor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZK287.4
    Official Full Name
    BPTI/Kunitz inhibitor domain-containing protein
    Primary source
    WormBase:WBGene00013965
    Locus tag
    CELE_ZK287.4
    See related
    AllianceGenome:WB:WBGene00013965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZK287.4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (9680134..9685659, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CRC domain-containing protein Neighboring gene STAS domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Activin_recp domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-box protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. Gomes JE, et al. J Cell Biol, 2013 Aug 5. PMID 23918937, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BPTI/Kunitz inhibitor domain-containing protein
    NP_001256131.1
    • Confirmed by transcript evidence
    NP_001256132.1
    • Confirmed by transcript evidence
    NP_001256133.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9680134..9685659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269204.4 → NP_001256133.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23456
      Conserved Domains (4) summary
      smart00131
      Location:1215 → 1259
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:318 → 369
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:256 → 309
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:45 → 91
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    2. NM_001269202.3 → NP_001256131.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256131.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU06
      Conserved Domains (4) summary
      cd00109
      Location:318 → 369
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:256 → 309
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:45 → 91
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00101
      Location:986 → 1030
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    3. NM_001269203.3 → NP_001256132.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU07
      Conserved Domains (4) summary
      cd00109
      Location:318 → 369
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:256 → 309
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:45 → 91
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00101
      Location:1015 → 1059
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    Nucleotide Protein
    Heading Accession and Version

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