dsh-1 DiSHevelled related [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dsh-1
Official Full Name: DiSHevelled related
Primary source: WormBase:WBGene00001101
Locus tag: CELE_C34F11.9
See related: AllianceGenome:WB:WBGene00001101
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables receptor tyrosine kinase binding activity. Involved in Wnt signaling pathway, regulating spindle positioning. Predicted to be active in cytosol. Is expressed in several structures, including head; intestine; neurons; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to human DVL1 (dishevelled segment polarity protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dsh-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 15

Sequence:: Chromosome: II; NC_003280.10 (5214400..5225377, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIN-17 and DSH-1/Dishevelled proteins were recruited to the pruning neurites in lin-44-dependent manners.
Title: Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans.
Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans.
Title: Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans.
conserved PCP-like pathway consisting of VANG-1/Van Gogh, PRKL-1/Prickle, and DSH-1/Dishevelled is involved in maintaining the polarized morphology of a subset of neurons in the nematode C. elegans.
Title: VANG-1 and PRKL-1 cooperate to negatively regulate neurite formation in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C34F11.9a (e-PCR)
- UniSTS:319891

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, regulating spindle positioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DiSHevelled related

NP_001300520.1

Product from WormBase gene class dsh;
Confirmed by transcript evidence

NP_001300521.1

Product from WormBase gene class dsh;
Confirmed by transcript evidence

NP_001300522.1

Product from WormBase gene class dsh;
Partially confirmed by transcript evidence

NP_001379729.1

Product from WormBase gene class dsh;
Partially confirmed by transcript evidence

NP_001379730.1

Product from WormBase gene class dsh;
Confirmed by transcript evidence

NP_494978.4

Product from WormBase gene class dsh;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5214400..5225377 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062577.9 → NP_494978.4 DiSHevelled related [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494978.4

Status: REVIEWED

UniProtKB/TrEMBL

H2KZ17

Conserved Domains (3) summary

smart00021
Location:69 → 152

DAX; Domain present in Dishevelled and axin

cd04438
Location:483 → 564

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam00595
Location:303 → 388

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001313591.3 → NP_001300520.1 DiSHevelled related [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AQZ1

Conserved Domains (2) summary

cd04438
Location:287 → 368

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam00595
Location:107 → 192

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001313592.3 → NP_001300521.1 DiSHevelled related [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AUI8

Conserved Domains (2) summary

cd04438
Location:762 → 843

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam00595
Location:582 → 667

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001313593.3 → NP_001300522.1 DiSHevelled related [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWU4

Conserved Domains (2) summary

cd04438
Location:287 → 368

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam00595
Location:107 → 192

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001393064.1 → NP_001379730.1 DiSHevelled related [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

B7WN58

Conserved Domains (3) summary

smart00021
Location:69 → 152

DAX; Domain present in Dishevelled and axin

cd04438
Location:483 → 564

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam00595
Location:303 → 388

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001393065.1 → NP_001379729.1 DiSHevelled related [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

B1Q240

Conserved Domains (2) summary

cd04438
Location:762 → 843

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam00595
Location:582 → 667

PDZ; PDZ domain (Also known as DHR or GLGF)