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    haf-2 ABC-type antigen peptide transporter [ Caenorhabditis elegans ]

    Gene ID: 174204, updated on 9-Dec-2024

    Summary

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    Official Symbol
    haf-2
    Official Full Name
    ABC-type antigen peptide transporter
    Primary source
    WormBase:WBGene00001812
    Locus tag
    CELE_F43E2.4
    See related
    AllianceGenome:WB:WBGene00001812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be active in membrane. Is expressed in intestine and muscle cell. Orthologous to human ABCB9 (ATP binding cassette subfamily B member 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See haf-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (7353576..7356426, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene NR LBD domain-containing protein Neighboring gene Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D Neighboring gene Protein inscuteable homologue C-terminal domain-containing protein Neighboring gene peptide-methionine (S)-S-oxide reductase Neighboring gene Ovule protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans. Yan R, et al. Vet Parasitol, 2012 Dec 21. PMID 22840641
    2. Comparative genomics and adaptive selection of the ATP-binding-cassette gene family in caenorhabditis species. Zhao Z, et al. Genetics, 2007 Mar. PMID 17194779, Free PMC Article
    3. Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response. Mao XR, et al. Cell Death Dis, 2016 Feb 25. PMID 26913604, Free PMC Article
    4. Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle. Schroeder LK, et al. Mol Biol Cell, 2007 Mar. PMID 17202409, Free PMC Article
    5. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ABC-type antigen peptide transporter
    NP_495537.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7353576..7356426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063136.7 → NP_495537.2  ABC-type antigen peptide transporter [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02086
      Conserved Domains (3) summary
      cd03249
      Location:526 → 764
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      TIGR00958
      Location:15 → 761
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:215 → 478
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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