acy-1 adenylate cyclase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: acy-1
Official Full Name: adenylate cyclase
Primary source: WormBase:WBGene00000068
Locus tag: CELE_F17C8.1
See related: AllianceGenome:WB:WBGene00000068
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable adenylate cyclase activity. Involved in several processes, including locomotory exploration behavior; memory; and regulation of defecation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in body wall musculature; ganglia; neurons; ventral nerve cord; and vulval muscle. Orthologous to human ADCY9 (adenylate cyclase 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See acy-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 13

Sequence:: Chromosome: III; NC_003281.10 (4722095..4730919)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin is one of three essential presynaptic SNARE proteins that acts in concert with other proteins to mediate fusion of synaptic vesicles with the presynaptic membrane.
Title: A gain-of-function mutation in adenylate cyclase confers isoflurane resistance in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F17C8.1 (e-PCR)
- UniSTS:309801

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of defecation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: adenylate cyclase

NP_497970.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4722095..4730919

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065569.5 → NP_497970.1 adenylate cyclase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497970.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19523

Conserved Domains (4) summary

smart00044
Location:297 → 469

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:317 → 503

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

cl00573
Location:773 → 982

SDF; Sodium:dicarboxylate symporter family

cl01087
Location:127 → 223

MreD; rod shape-determining protein MreD