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    lfi-1 Rootletin-like coiled-coil domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lfi-1
    Official Full Name
    Rootletin-like coiled-coil domain-containing protein
    Primary source
    WormBase:WBGene00022500
    Locus tag
    CELE_ZC8.4
    See related
    AllianceGenome:WB:WBGene00022500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in kinetochore microtubule and nucleus. Orthologous to several human genes including CROCC (ciliary rootlet coiled-coil, rootletin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lfi-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    22
    Sequence:
    Chromosome: X; NC_003284.9 (4976830..4993242)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Phosphatidylinositol 4-kinase type 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MYND-type domain-containing protein Neighboring gene 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of critical domains and putative partners for the Caenorhabditis elegans spindle component LIN-5. Fisk Green R, et al. Mol Genet Genomics, 2004 Jun. PMID 15138888
    2. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article
    3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rootletin-like coiled-coil domain-containing protein
    NP_001362032.1
    • Partially confirmed by transcript evidence
    NP_001362033.1
    • Partially confirmed by transcript evidence
    NP_001371014.1
    • Confirmed by transcript evidence
    NP_001407547.1
    • Confirmed by transcript evidence
    NP_001407548.1
    • Confirmed by transcript evidence
    NP_508848.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4976830..4993242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375027.2 → NP_001362033.1  Rootletin-like coiled-coil domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0I4
      Conserved Domains (4) summary
      COG1196
      Location:651 → 1496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1235 → 2133
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR03794
      Location:2065 → 2216
      NHLM_micro_HlyD; NHLM bacteriocin system secretion protein
      pfam15035
      Location:191 → 429
      Rootletin; Ciliary rootlet component, centrosome cohesion

    2. NM_076447.6 → NP_508848.2  Rootletin-like coiled-coil domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508848.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0I2
      Conserved Domains (9) summary
      TIGR02168
      Location:1157 → 2044
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04523
      Location:602 → 1378
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam10211
      Location:1783 → 1853
      Ax_dynein_light; Axonemal dynein light chain
      pfam15035
      Location:195 → 433
      Rootletin; Ciliary rootlet component, centrosome cohesion
      pfam15619
      Location:1913 → 2083
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl00143
      Location:683 → 785
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cl00459
      Location:1129 → 1268
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:960 → 1048
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:2039 → 2146
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_001383570.1 → NP_001371014.1  Rootletin-like coiled-coil domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5E4LWV7
      Conserved Domains (4) summary
      COG1196
      Location:660 → 1505
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4372
      Location:492 → 715
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:1244 → 2142
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:200 → 438
      Rootletin; Ciliary rootlet component, centrosome cohesion

    4. NM_001420571.1 → NP_001407547.1  Rootletin-like coiled-coil domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5E4M3N2

    5. NM_001420572.1 → NP_001407548.1  Rootletin-like coiled-coil domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5E4LZU4

    6. NM_001375029.2 → NP_001362032.1  Rootletin-like coiled-coil domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0I3
      Conserved Domains (4) summary
      COG1196
      Location:582 → 1427
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1166 → 2064
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR03794
      Location:1996 → 2147
      NHLM_micro_HlyD; NHLM bacteriocin system secretion protein
      pfam15035
      Location:122 → 360
      Rootletin; Ciliary rootlet component, centrosome cohesion
    Nucleotide Protein
    Heading Accession and Version

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