gcy-9 Receptor-type guanylate cyclase gcy-9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gcy-9
Official Full Name: Receptor-type guanylate cyclase gcy-9
Primary source: WormBase:WBGene00001536
Locus tag: CELE_ZK455.2
See related: AllianceGenome:WB:WBGene00001536
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in several processes, including calcium-mediated signaling; cellular response to acidic pH; and positive regulation of neuronal action potential. Located in neuronal cell body and non-motile cilium. Is expressed in BAGL and BAGR. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gcy-9 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 24

Sequence:: Chromosome: X; NC_003284.9 (11332110..11337883, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

One component of the BAG transduction pathway, the receptor-type guanylate cyclase GCY-9, suffices to confer cellular sensitivity to both molecular CO2 and acid, indicating that it is a bifunctional chemoreceptor.
Title: A chemoreceptor that detects molecular carbon dioxide.
Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons
Title: A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity.
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
Title: Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK455.2 (e-PCR)
- UniSTS:310494

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in detection of carbon dioxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Receptor-type guanylate cyclase gcy-9

NP_509897.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11332110..11337883 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077496.6 → NP_509897.3 Receptor-type guanylate cyclase gcy-9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

E7EAU8, Q23496

Conserved Domains (6) summary

smart00044
Location:862 → 1054

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:889 → 1076

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:69 → 404

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:837 → 883

HNOBA; Heme NO binding associated

cl10011
Location:66 → 416

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21453
Location:550 → 820

PKc_like; Protein Kinases, catalytic domain