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    F57B9.3 RNA helicase [ Caenorhabditis elegans ]

    Gene ID: 186440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F57B9.3
    Official Full Name
    RNA helicase
    Primary source
    WormBase:WBGene00018997
    Locus tag
    CELE_F57B9.3
    See related
    AllianceGenome:WB:WBGene00018997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation initiation factor activity. Involved in translation. Predicted to be located in P granule. Predicted to be active in cytoplasmic stress granule. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F57B9.3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (6939823..6941906)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cell adhesion protein byn-1 Neighboring gene Tyrosine-protein kinase Neighboring gene 4-hydroxybenzoate polyprenyltransferase, mitochondrial Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene CCR4-NOT transcription complex subunit let-711

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling. Lee EC, et al. Am J Physiol Cell Physiol, 2012 Dec 15. PMID 23076791, Free PMC Article
    2. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response HEP PubMed 
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA helicase
    NP_498514.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6939823..6941906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066113.3 → NP_498514.2  RNA helicase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20935
      Conserved Domains (3) summary
      PTZ00424
      Location:19 → 391
      PTZ00424; helicase 45; Provisional
      pfam00271
      Location:243 → 352
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:29 → 221
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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