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    tir-1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tir-1
    Official Full Name
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1
    Primary source
    WormBase:WBGene00006575
    Locus tag
    CELE_F13B10.1
    See related
    AllianceGenome:WB:WBGene00006575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables several functions, including NAD+ nucleosidase activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm and cell body. Is expressed in head; intestine; and pharynx. Used to study amyotrophic lateral sclerosis. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tir-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (3869590..3901642, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Acetyl-coenzyme A synthetase Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL3 Neighboring gene putative methylmalonyl-CoA mutase, mitochondrial Neighboring gene Integrin beta pat-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immobilization of C. elegans with different concentrations of an anesthetic for time-lapse imaging of dynamic protein trafficking in neurons. Siete C, et al. MicroPubl Biol, 2024. PMID 38298463, Free PMC Article
    2. Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling. Finger F, et al. Nat Metab, 2019 Mar. PMID 31535080, Free PMC Article
    3. Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Khazma T, et al. Cell Rep, 2023 Sep 26. PMID 37635352, Free PMC Article
    4. A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration. Loring HS, et al. Elife, 2021 Jun 29. PMID 34184985, Free PMC Article
    5. SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism. Icso JD, et al. Biochemistry, 2023 Jul 4. PMID 37307562, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity.
      Title: Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity.
    2. The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.
      Title: The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.
    3. A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration.
      Title: A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration.
    4. Thus, Bifidobacterium longum BB68 increased the longevity of nematodes by activating the TIR-1 - JNK-1 - DAF-16 signaling pathway, and the cell wall component of BB68 contributed to longevity.
      Title: The Transcription Factor DAF-16 is Essential for Increased Longevity in C. elegans Exposed to Bifidobacterium longum BB68.
    5. show that the expression of mutant proteins causative for ALS in Caenorhabditis elegans motor neurons induces an innate immune response via TIR-1/Sa
      Title: Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons.
    6. The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic left/right neuronal asymmetry in C. elegans.
      Title: The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic L/R neuronal asymmetry in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antibacterial innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to axon injury IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within serotonin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1
    NP_001021251.2
    • Confirmed by transcript evidence
    NP_001299866.1
    • Confirmed by transcript evidence
    NP_001299868.1
    • Confirmed by transcript evidence
    NP_001367074.1
    • Confirmed by transcript evidence
    NP_001368535.1
    • Confirmed by transcript evidence
    NP_001370174.1
    • Partially confirmed by transcript evidence
    NP_497784.1
    • Confirmed by transcript evidence
    NP_497785.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3869590..3901642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065383.6 → NP_497784.1  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5I9W1
      Conserved Domains (4) summary
      cd09501
      Location:557 → 625
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:626 → 695
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:557 → 622
      SAM; Sterile alpha motif
      smart00255
      Location:707 → 850
      TIR; Toll - interleukin 1 - resistance

    2. NM_001026080.5 → NP_001021251.2  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17801, O17802, Q19373, Q7JMF4, Q7JMF5, Q86DA5
      UniProtKB/TrEMBL
      Q5I9W1
      Conserved Domains (3) summary
      cd09501
      Location:611 → 679
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:680 → 749
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00255
      Location:761 → 904
      TIR; Toll - interleukin 1 - resistance

    3. NM_001381812.1 → NP_001367074.1  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5I9W1
      Conserved Domains (3) summary
      cd09501
      Location:428 → 496
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:497 → 566
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00255
      Location:578 → 721
      TIR; Toll - interleukin 1 - resistance

    4. NM_065384.7 → NP_497785.1  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5I9V9
      Conserved Domains (4) summary
      cd09501
      Location:216 → 284
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:285 → 354
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:216 → 281
      SAM; Sterile alpha motif
      smart00255
      Location:366 → 509
      TIR; Toll - interleukin 1 - resistance

    5. NM_001384059.3 → NP_001370174.1  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd09502
      Location:42 → 111
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00255
      Location:123 → 266
      TIR; Toll - interleukin 1 - resistance
      cl15755
      Location:1 → 41
      SAM_superfamily; SAM (Sterile alpha motif )

    6. NM_001381811.1 → NP_001368535.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AX54, Q5I9W1
      Conserved Domains (3) summary
      cd09501
      Location:557 → 625
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:626 → 695
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00255
      Location:707 → 850
      TIR; Toll - interleukin 1 - resistance

    7. NM_001312937.3 → NP_001299866.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5I9W0, Q5I9W1
      Conserved Domains (4) summary
      cd09501
      Location:611 → 679
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:680 → 749
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:611 → 676
      SAM; Sterile alpha motif
      smart00255
      Location:761 → 904
      TIR; Toll - interleukin 1 - resistance

    8. NM_001312939.3 → NP_001299868.1  Sterile alpha and TIR motif-containing protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ART9
      Conserved Domains (4) summary
      cd09502
      Location:42 → 111
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:43 → 112
      SAM; Sterile alpha motif
      smart00255
      Location:123 → 266
      TIR; Toll - interleukin 1 - resistance
      cl15755
      Location:1 → 41
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86DA5.2

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