rfc-4 Replication factor C subunit 4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rfc-4
Official Full Name: Replication factor C subunit 4
Primary source: WormBase:WBGene00004340
Locus tag: CELE_F31E3.3
See related: AllianceGenome:WB:WBGene00004340
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to contribute to DNA clamp loader activity. Involved in DNA replication. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC4 (replication factor C subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rfc-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (6972253..6973717)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F31E3.3 (e-PCR)
- UniSTS:314173

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA clamp loader activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DNA replication factor C complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Replication factor C subunit 4

NP_498521.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6972253..6973717

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066120.8 → NP_498521.1 Replication factor C subunit 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498521.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P53016

Conserved Domains (2) summary

cd00009
Location:32 → 169

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

PHA02544
Location:12 → 329

44; clamp loader, small subunit; Provisional