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    dkc-1 Putative H/ACA ribonucleoprotein complex subunit 4 [ Caenorhabditis elegans ]

    Gene ID: 176504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dkc-1
    Official Full Name
    Putative H/ACA ribonucleoprotein complex subunit 4
    Primary source
    WormBase:WBGene00010478
    Locus tag
    CELE_K01G5.5
    See related
    AllianceGenome:WB:WBGene00010478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable pseudouridine synthase activity. Predicted to be involved in box H/ACA sno(s)RNA 3'-end processing and pseudouridine synthesis. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in X-linked dyskeratosis congenita; aplastic anemia; and dyskeratosis congenita. Orthologous to human DKC1 (dyskerin pseudouridine synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dkc-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (10748429..10750080)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Exostosin-2 homolog Neighboring gene GTP-binding nuclear protein ran-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ENhancer of Uncoordination Neighboring gene Chromobox protein homolog hpl-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PLP-1 binds nematode double-stranded telomeric DNA. Im SH, et al. Mol Cells, 2005 Oct 31. PMID 16267406
    2. Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins. Aftab MN, et al. BMC Genomics, 2008 Jun 11. PMID 18547420, Free PMC Article
    3. Nucleotide modifications in messenger RNA and their role in development and disease. Dezi V, et al. Biochem Soc Trans, 2016 Oct 15. PMID 27911721
    4. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article
    5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in box H/ACA sno(s)RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative H/ACA ribonucleoprotein complex subunit 4
    NP_499370.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10748429..10750080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066969.7 → NP_499370.1  Putative H/ACA ribonucleoprotein complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17919
      Conserved Domains (4) summary
      cd02572
      Location:76 → 258
      PseudoU_synth_hDyskerin; Pseudouridine synthase, human dyskerin like
      TIGR00425
      Location:44 → 369
      CBF5; rRNA pseudouridine synthase, putative
      pfam01472
      Location:285 → 358
      PUA; PUA domain
      pfam08068
      Location:38 → 94
      DKCLD; DKCLD (NUC011) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17919.1

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