sphk-1 Sphingosine kinase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sphk-1
Official Full Name: Sphingosine kinase 1
Primary source: WormBase:WBGene00007918
Locus tag: CELE_C34C6.5
See related: AllianceGenome:WB:WBGene00007918
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable D-erythro-sphingosine kinase activity and acetyltransferase activity. Involved in mitochondrial unfolded protein response; positive regulation of acetylcholine secretion, neurotransmission; and regulation of locomotion. Located in several cellular components, including mitochondrion; neuronal cell body; and presynaptic periactive zone. Is expressed in several structures, including body wall musculature; excretory canal; intestine; linker cell; and neurons. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SPHK1 (sphingosine kinase 1) and SPHK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sphk-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (8699012..8701669, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, through a combination of genetic, behavioral, and fluorescent imaging approaches, we found that sphingosine kinase functions in the SKN-1/Nrf2 pathway in the intestine to regulate neuropeptide biogenesis and secretion in motor neurons.
Title: Sphingosine Kinase Regulates Neuropeptide Secretion During the Oxidative Stress-Response Through Intertissue Signaling.
This study shows that SPHK-1 promotes neurotransmitter release in vivo and identifies a novel muscarinic pathway that regulates SphK abundance at presynaptic terminals.
Title: Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

STS2-167 (e-PCR)
- UniSTS:241837

C34C6.5 (e-PCR)
- UniSTS:309240

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-erythro-sphingosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-erythro-sphingosine kinase activity	IEA Inferred from Electronic Annotation more info
enables D-erythro-sphingosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables sphingosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitochondrial unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of acetylcholine secretion, neurotransmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of acetylcholine secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic periactive zone	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sphingosine kinase 1

NP_001022017.1

Confirmed by transcript evidence

NP_001254179.1

Confirmed by transcript evidence

NP_001254180.1

Confirmed by transcript evidence

NP_001367075.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8699012..8701669 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026846.4 → NP_001022017.1 Sphingosine kinase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022017.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D2Y8W1, H9G2Q9, Q18425, Q7JM91

Conserved Domains (2) summary

COG1597
Location:89 → 469

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

pfam00781
Location:88 → 189

DAGK_cat; Diacylglycerol kinase catalytic domain
NM_001267250.2 → NP_001254179.1 Sphingosine kinase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254179.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18425

Conserved Domains (2) summary

COG1597
Location:10 → 390

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

pfam00781
Location:9 → 110

DAGK_cat; Diacylglycerol kinase catalytic domain
NM_001381535.1 → NP_001367075.1 Sphingosine kinase 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN02958
Location:38 → 402

PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
NM_001267251.3 → NP_001254180.1 Sphingosine kinase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254180.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18425

Conserved Domains (2) summary

PLN02958
Location:5 → 317

PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

cl01255
Location:5 → 83

DAGK_cat; Diacylglycerol kinase catalytic domain