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    ptp-1 Tyrosine-protein phosphatase 1 [ Caenorhabditis elegans ]

    Gene ID: 175463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptp-1
    Official Full Name
    Tyrosine-protein phosphatase 1
    Primary source
    WormBase:WBGene00004213
    Locus tag
    CELE_C48D5.2
    See related
    AllianceGenome:WB:WBGene00004213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in sarcoplasmic reticulum. Is expressed in muscle cell; nerve ring; neurons; pharyngeal nervous system; and ventral nerve cord. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3) and PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ptp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    19
    Sequence:
    Chromosome: III; NC_003281.10 (3590722..3611971)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein lag-3 Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein mS31

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel stress regulated FERM domain containing cytosolic protein having PTP activity in Setaria cervi, a bovine filarial parasite. Singh N, et al. Biochem Biophys Res Commun, 2015 Feb 27. PMID 25645020
    2. Yeast two-hybrid screening identifies MPZ-1 and PTP-1 as candidate scaffolding proteins of metabotropic glutamate receptors in Caenorhabditis elegans. Dillon J, et al. Invert Neurosci, 2018 Nov 11. PMID 30417267
    3. Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Didiano D, et al. Nat Struct Mol Biol, 2006 Sep. PMID 16921378
    4. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden D, et al. Dev Biol, 2004 Aug 1. PMID 15242805
    5. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    Tyrosine-protein phosphatase 1
    NP_497732.1
    • Confirmed by transcript evidence
    NP_497733.1
    • Confirmed by transcript evidence
    NP_741112.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3590722..3611971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065331.4 → NP_497732.1  Tyrosine-protein phosphatase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497732.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28191, P45449, Q8MM81, Q9U3N7
      Conserved Domains (8) summary
      smart00194
      Location:752 → 1010
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:30 → 226
      B41; Band 4.1 homologues
      cd00047
      Location:780 → 1009
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:615 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:220 → 313
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:117 → 226
      FERM_M; FERM central domain
      pfam08736
      Location:323 → 362
      FA; FERM adjacent (FA)
      pfam09379
      Location:33 → 100
      FERM_N; FERM N-terminal domain

    2. NM_171099.5 → NP_741112.1  Tyrosine-protein phosphatase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741112.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28191
      Conserved Domains (3) summary
      smart00194
      Location:315 → 573
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:343 → 572
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:178 → 266
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. NM_065332.4 → NP_497733.1  Tyrosine-protein phosphatase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497733.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28191
      Conserved Domains (3) summary
      smart00194
      Location:350 → 608
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:378 → 607
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:213 → 301
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28191.3

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