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    st3gal3a ST3 beta-galactoside alpha-2,3-sialyltransferase 3a [ Danio rerio (zebrafish) ]

    Gene ID: 393326, updated on 4-Jan-2025

    Summary

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    Official Symbol
    st3gal3aprovided by ZNC
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1322
    See related
    Ensembl:ENSDARG00000015374 AllianceGenome:ZFIN:ZDB-GENE-040426-1322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    siat6; st3gal3; st3ga3-r; zgc:63978
    Summary
    Predicted to enable N-acetyllactosaminide alpha-2,3-sialyltransferase activity. Predicted to act upstream of or within protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Is expressed in several structures, including cardiovascular system; integument; liver; pleuroperitoneal region; and ventral mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 12 and developmental and epileptic encephalopathy 15. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See st3gal3a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (3334378..3405497)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (3174069..3245200)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type Fa Neighboring gene lysine (K)-specific demethylase 4A, genome duplicate a Neighboring gene uncharacterized LOC108190362 Neighboring gene artemin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757
    2. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Yamakawa N, et al. Nat Commun, 2018 Nov 7. PMID 30405127, Free PMC Article
    3. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
    4. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC63978

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
    Names
    SIAT6-r
    ST3 beta-galactoside alpha-2,3-sialyltransferase 3
    sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
    st3gal3-r2
    NP_956649.2
    XP_021332477.1
    XP_021332479.1
    XP_021332480.1
    XP_021332481.1
    XP_068077772.1
    XP_068077773.1
    XP_068077774.1
    XP_068077775.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200355.2 → NP_956649.2  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a

      Status: VALIDATED

      Source sequence(s)
      BX119315
      UniProtKB/TrEMBL
      Q7T3B9
      Related
      ENSDARP00000107939.2, ENSDART00000130879.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      3334378..3405497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476802.2 → XP_021332477.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PLX6, Q7T3B9
      Conserved Domains (1) summary
      pfam00777
      Location:107 → 398
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_021476805.2 → XP_021332480.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M9QF92, Q7T3B9
      Conserved Domains (1) summary
      pfam00777
      Location:91 → 382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_068221671.1 → XP_068077772.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X3

      UniProtKB/TrEMBL
      Q7T3B9

    4. XM_021476806.2 → XP_021332481.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M9QF92, Q7T3B9
      Conserved Domains (1) summary
      pfam00777
      Location:91 → 382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_068221672.1 → XP_068077773.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X3

      UniProtKB/TrEMBL
      Q7T3B9

    6. XM_021476804.2 → XP_021332479.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PLX6, Q7T3B9
      Conserved Domains (1) summary
      pfam00777
      Location:107 → 398
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_068221674.1 → XP_068077775.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M9PLY0

    8. XM_068221673.1 → XP_068077774.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M9PLY0
    Nucleotide Protein Strain
    Heading Accession and Version

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