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    pwwp2a PWWP domain containing 2A [ Danio rerio (zebrafish) ]

    Gene ID: 559090, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pwwp2aprovided by ZNC
    Official Full Name
    PWWP domain containing 2Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-131120-4
    See related
    AllianceGenome:ZFIN:ZDB-GENE-131120-4
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-190f9.5
    Summary
    Orthologous to human PWWP2A (PWWP domain containing 2A). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See pwwp2a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30022899..30032113, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (29983061..29996059, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:ch73-190f9.4 Neighboring gene uncharacterized LOC137487235 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene fatty acid binding protein 6, ileal (gastrotropin) Neighboring gene cyclin J-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    PWWP domain-containing protein 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      30022899..30032113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_682396.10 → XP_687488.4  PWWP domain-containing protein 2A

      UniProtKB/TrEMBL
      A0A8N7T7B9
      Conserved Domains (1) summary
      cd05835
      Location:889 → 975
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    Nucleotide Protein Strain
    Heading Accession and Version

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