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    crema cAMP responsive element modulator a [ Danio rerio (zebrafish) ]

    Gene ID: 555432, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cremaprovided by ZNC
    Official Full Name
    cAMP responsive element modulator aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7031
    See related
    Ensembl:ENSDARG00000023217 AllianceGenome:ZFIN:ZDB-GENE-030131-7031
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk66d05; wu:fk66d05; si:dkey-177e13.4
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cAMP response element binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Is expressed in brain and telencephalon. Orthologous to human CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See crema in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (43159239..43196619, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (43308712..43347236, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487483 Neighboring gene finTRIM family, member 15 Neighboring gene par-3 family cell polarity regulator alpha, b Neighboring gene neuropilin 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inversely Regulated Inflammation-Related Processes Mediate Anxiety-Obesity Links in Zebrafish Larvae and Adults. Yehuda H, et al. Cells, 2023 Jul 6. PMID 37443828, Free PMC Article
    2. A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Pei DS, et al. Nucleic Acids Res, 2011 Apr. PMID 21172930, Free PMC Article
    3. AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair. Pei DS, et al. Cell Death Dis, 2019 Apr 25. PMID 31024003, Free PMC Article
    4. Gene responses in the central nervous system of zebrafish embryos exposed to the neurotoxicant methyl mercury. Ho NY, et al. Environ Sci Technol, 2013 Apr 2. PMID 23458150
    5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ATF4-CREB1 transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-responsive element modulator
    Names
    Zfcrem

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      43159239..43196619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171403.5 → XP_005171460.1  cAMP-responsive element modulator isoform X2

      UniProtKB/TrEMBL
      A0A8M2BIS5
      Conserved Domains (2) summary
      cd14690
      Location:205 → 259
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:28 → 66
      pKID; pKID domain

    2. XM_677932.10 → XP_683024.3  cAMP-responsive element modulator isoform X1

      See identical proteins and their annotated locations for XP_683024.3

      UniProtKB/TrEMBL
      A0A8N7T6W6, E7F9I0
      Related
      ENSDARP00000116638.1, ENSDART00000141087.2
      Conserved Domains (2) summary
      cd14690
      Location:244 → 298
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:67 → 105
      pKID; pKID domain

    3. XM_068214537.1 → XP_068070638.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A8N7T6W6, E7F9I0

    4. XM_068214533.1 → XP_068070634.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A8N7T6W6, E7F9I0

    5. XM_005171404.5 → XP_005171461.1  cAMP-responsive element modulator isoform X3

      UniProtKB/TrEMBL
      A0A8M2BIR3, E9QD53
      Related
      ENSDARP00000112661.1, ENSDART00000132588.3
      Conserved Domains (1) summary
      cd14690
      Location:54 → 108
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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